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Other Thrombotic Microangiopathies

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Infection-associated Hemolytic Uremic Syndrome

Infection-associated Hemolytic Uremic Syndrome or IA-HUS refers to a TMA that has an infectious etiology.

This TMA is associated with infection by Escherichia coli  which expresses Shiga toxin.  In these cases, the TMA follows 5-7 days after the acute infection and the typical hemorrhagic colitis.  Infection with other subtypes of E. coli, Shigella, Salmonella, and Campylobacter can present similar. 

 

In these cases, patients will present with an acute TMA and renal failure, may be difficult to distinguish from CM-HUS and other forms of TMA.  

Treatment for this form of TMA is largely supportive with the majority of patients recovering from their acute illness.